Clinical value of metabolic tumor volume by PET/CT in extranodal natural killer/T cell lymphoma.

This study investigated whether metabolic tumor volume (MTV) by PET/CT as indicator of extent of lymphoma burden would be a prognostic factor in stage I(E)/II(E) extranodal natural killer/T cell lymphoma (ENKTCL). Eighty patients with stage I(E)/II(E) ENKTCL in the upper aerodigestive tract underwent PET/CT at diagnosis were enrolled and 32 patients received upfront radiotherapy (RTx). MTV was measured on PET/CT images by the extranodal region above SUV, 2.5. Receiver operating curve analyses indicated that an MTV of 35.2 cm(3) was the ideal cut-off to distinguish between low and high MTV groups. Clinical outcomes were compared according to several prognostic factors (age, stage, high performance status [PS], high International Prognostic Index, elevated lactate dehydrogenase [LDH], local tumor invasiveness [LTI], high MTV and up-front RT). High PS, elevated LDH, LTI, high MTV and upfront RT were associated with survivals. In multivariate analysis, high MTV (PFS, HR=4.170, 95% CI=1.714-10.147, p=0.002; OS, HR=4.102, 95% CI=1.617-10.408, p=0.003) and up-front RT (PFS, HR=0.410, 95%CI=0.178-0.946, p=0.037; OS, HR=0.365, 95% CI=0.152-0.872, p=0.023) were significant independent prognostic factors. Upfront RTx and extent of tumor burden, as measured by the MTV, had significant prognostic value in patients with ENKTCL. Published by Elsevier Ltd.

Citation

Moo-Kon Song, Joo-Seop Chung, Ho-Jin Shin, Joon-Ho Moon, Jae-Sook Ahn, Ho-Sup Lee, Sang-Min Lee, Gyeong-Won Lee, Seong-Jang Kim, Seok-Mo Lee. Clinical value of metabolic tumor volume by PET/CT in extranodal natural killer/T cell lymphoma. Leukemia research. 2013 Jan;37(1):58-63

Mesh Tags

PMID: 23040533

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