Sustained response to weekly vinblastine in 2 children with pilomyxoid astrocytoma associated with diencephalic syndrome.

Gurpreet Singh, Xing Chang Wei, Walter Hader, Jennifer A Chan, Eric Bouffet, Lucie Lafay-Cousin

Department of Pediatric Hematology Oncology and Bone Marrow Transplantation, Alberta Children's Hospital, ON, Canada.

Journal of pediatric hematology/oncology 2013 Mar

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Diencephalic syndrome (DS) related to hypothalamic/chiasmatic region tumor has mainly been reported with low-grade glioma. We described 2 young children with DS related to pilomyxoid astrocytoma. Despite the recognized more agressive clinical behavior of this histologic subtype, we report successful resolution of DS and sustained tumor response with prolonged use of single-agent vinblastine.

Citation

Gurpreet Singh, Xing Chang Wei, Walter Hader, Jennifer A Chan, Eric Bouffet, Lucie Lafay-Cousin. Sustained response to weekly vinblastine in 2 children with pilomyxoid astrocytoma associated with diencephalic syndrome. Journal of pediatric hematology/oncology. 2013 Mar;35(2):e53-6