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Be my guest: two acyclic cucurbit[n]uril-type receptors that carry SO(3) (-) -groups bind tightly to several commonly used neuromuscular blocking agents, such as rocuronium, in aqueous solution as revealed by direct and competitive UV/Vis binding assays. One of these containers functions as a potent reversal agent for rocuronium-induced neuromuscular block in rats. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Da Ma, Ben Zhang, Ulrike Hoffmann, Martina Grosse Sundrup, Matthias Eikermann, Lyle Isaacs. Acyclic cucurbit[n]uril-type molecular containers bind neuromuscular blocking agents in vitro and reverse neuromuscular block in vivo. Angewandte Chemie (International ed. in English). 2012 Nov 5;51(45):11358-62

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PMID: 23047893

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