Research progress of cell dedifferentiation induced by reversine].

Xuqi Hu, Xiaolei Zhang, Yifei Zhou, Yang Yu, Huazi Xu

Department of Orthopaedics, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou Zhejiang 325000, PR China.

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 2012 Sep

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To review the research progress of different ways of stem cells generation and cells dedifferentiation induced by reversine. The papers related to reversine inducing cells dedifferentiation and stem cells generation were reviewed. To obtain stem cells, there are always some disadvantages via somatic cell nuclear transfer or gene transfection. However reversine, a small molecule, can induce cells dedifferentiation which has unique advantage. But its mechanism is still unclear. The chemical approach for generation of induced pluripotent stem cells by reversine may take the place of other methods.

Citation

Xuqi Hu, Xiaolei Zhang, Yifei Zhou, Yang Yu, Huazi Xu. Research progress of cell dedifferentiation induced by reversine]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery. 2012 Sep;26(9):1126-9