Antioxidant evaluation of heterocyclic compounds by cytokinesis-block micronucleus assay.

Dejan Godevac, Vele Tesević, Vlatka Vajs, Slobodan Milosavljević, Miroslava Stanković

Institute of Chemistry, Technology and Metallurgy, Njegoseva 12, University of Belgrade, Serbia. dgodjev@chem.bg.ac.rs

Mini reviews in medicinal chemistry 2013 Mar

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This article summarizes the results of using cytokinesis-block micronucleus (CBMN) assay to evaluate the antioxidant potential of heterocyclic compounds. Most studies were carried out with naturally occurring heterocyclic compounds such as plant polyphenols: flavonoids, xanthones, coumarins, and ellagitannins, or plant derived products (juices, extracts, supplements) rich in bioactive heterocyclic compounds. There are also some studies dealing with synthetic heterocyclic antioxidants. CBMN assay is an in vitro study that has been used to evaluate antioxidant and protective effects of heterocyclic compounds on induced chromosome aberration in human lymphocytes.

Citation

Dejan Godevac, Vele Tesević, Vlatka Vajs, Slobodan Milosavljević, Miroslava Stanković. Antioxidant evaluation of heterocyclic compounds by cytokinesis-block micronucleus assay. Mini reviews in medicinal chemistry. 2013 Mar;13(3):431-8