Nonfatal suicidal overdose of olanzapine in an adolescent.

Lokesh Kumar Singh, Samir Kumar Praharaj, Manoj Sahu

Department of Psychiatry, Pandit Jawaharlal Nehru Memorial Medical College & Dr. Bhimrao Ambedkar MemorialHospital, Raipur, Chhattisgarh 492001, India.

Current drug safety 2012 Sep

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The atypical antipsychotic olanzapine is increasingly being used for various psychiatric conditions. There are few reports of olanzapine overdose in adolescent population. We report a case of 16-year-old adolescent who ingested 750 mg olanzapine, the highest reported nonlethal dose of olanzapine in adolescents. He presented with tachycardia, hypotension, generalized myoclonus, hyperpyrexia, muscular rigidity, leukocytosis and elevated creatine phosphokinase (CPK) levels. He recovered from the toxicity with minimal intervention.

Citation

Lokesh Kumar Singh, Samir Kumar Praharaj, Manoj Sahu. Nonfatal suicidal overdose of olanzapine in an adolescent. Current drug safety. 2012 Sep;7(4):328-9