Effect of endogenous steroid hormones on 17-alpha-hydroxyprogesterone caproate metabolism.

Courtney D Cuppett, Yang Zhao, Steve Caritis, Shimin Zhang, Wenchen Zhao, Raman Venkataramanan

American journal of obstetrics and gynecology 2013 Jan

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Plasma concentrations of 17-alpha-hydroxyprogesterone caproate (17-OHPC) vary substantially in pregnant patients who receive an identical dose. Endogenous steroid hormones may alter 17-OHPC metabolism, which contributes to this large variability. Pooled human liver microsomes were incubated with 17-OHPC alone or in combination with progesterone, hydroxyprogesterone, estrone, estradiol, or estriol. High-performance liquid chromatography with ultraviolet detection was used to quantify 17-OHPC. Under the conditions that were studied, 17-OHPC metabolism was inhibited by 37% by a combination of endogenous steroid hormones. Progesterone alone significantly inhibited 17-OHPC metabolism by 28% (P < .001). 17-OHPC metabolism is inhibited significantly by endogenous steroids and, in particular, progesterone. This effect may account for some of the large variation in plasma 17-OHPC concentrations that is seen in pregnant patients who receive a fixed dose of medication. Copyright © 2013 Mosby, Inc. All rights reserved.

Citation

Courtney D Cuppett, Yang Zhao, Steve Caritis, Shimin Zhang, Wenchen Zhao, Raman Venkataramanan. Effect of endogenous steroid hormones on 17-alpha-hydroxyprogesterone caproate metabolism. American journal of obstetrics and gynecology. 2013 Jan;208(1):86.e1-6