Factor friction: protective and pathogenic roles for complement factors in immune complex glomerulonephritis.

Division of Nephrology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA. Joshua.Thurman@ucdenver.edu

Kidney international 2012 Nov

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The classical pathway of complement is activated in patients with immune complex glomerulonephritis. However, Alexander et al. demonstrate that factor H, an alternative pathway regulator, is critical for protecting mice from immune-complex-mediated glomerular injury. In mice that lack factor H, signaling through the C5a receptor is necessary for the development of injury. These results suggest that factor H may be critical for limiting injury in a wide range of autoimmune and inflammatory renal diseases.

Citation

Joshua M Thurman. Factor friction: protective and pathogenic roles for complement factors in immune complex glomerulonephritis. Kidney international. 2012 Nov;82(9):945-7