Atypical E2Fs drive atypical cell cycles.

Joy H Meserve, Robert J Duronio

Nature cell biology 2012 Nov

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It is well documented that polyploid cells exist in mammalian tissues such as the placenta and liver, but their function and the mechanisms for their formation have remained elusive. Two studies now identify a role for atypical E2F transcription factors in promoting polyploidy in mammals and challenge present theories about the function of polyploidy.