Increasing the heme-dependent respiratory efficiency of Lactococcus lactis by inhibition of lactate dehydrogenase.

The discovery of heme-induced respiration in Lactococcus lactis has radically improved the industrial processes used for the biomass production of this species. Here, we show that inhibition of the lactate dehydrogenase activity of L. lactis during growth under respiration-permissive conditions can stimulate aerobic respiration, thereby increasing not only growth efficiency but also the robustness of this organism.

Citation

Stefania Arioli, Daniele Zambelli, Simone Guglielmetti, Ivano De Noni, Martin B Pedersen, Per Dedenroth Pedersen, Fabio Dal Bello, Diego Mora. Increasing the heme-dependent respiratory efficiency of Lactococcus lactis by inhibition of lactate dehydrogenase. Applied and environmental microbiology. 2013 Jan;79(1):376-80

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PMID: 23064338

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