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The present study aimed to detect serum fetuin-A levels in knee osteoarthritis (OA) patients and to investigate their correlation with clinical severity. We enrolled 215 knee OA patients and 76 healthy controls. We measured serum fetuin-A levels by enzyme-linked immunosorbent assay and assessed the correlation between serum fetuin-A levels and Kellgren-Lawrence grades as well as Western Ontario and McMaster Universities Arthritis Index scores in OA patients. Our results demonstrated that serum fetuin-A levels were independently and negatively correlated with greater clinical severity in OA patients.


Jie Xiao, Xiang-Rui Wang, Kong-Zu Hu, Mao-Qiang Li, Jian-Wei Chen, Tao Ma, Zhan-Chun Li. Serum fetuin-A levels are inversely associated with clinical severity in patients with primary knee osteoarthritis. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2013 Feb;18(1):51-4

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PMID: 23066960

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