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The intestinal protozoan parasite Giardia lamblia is one of the most common causes of diarrhoea and undergoes antigenic variation. In pathogenic microorganisms, antigenic variation is often described as a mechanism to evade the host immune system, resulting in chronic and/or recurrent infections. In the recent years, significant advances in the knowledge of the antigen switching process have been achieved. Here we review the principal knowledge on the mechanisms that regulate this process, including genomic organization, post-transcriptional gene silencing, expressional modifications, and processing and turnover of VSPs.

Citation

Xian-Min Feng, Yue-Hua Wang, Xiao-Hong Ju. Research progress on the mechanisms of antigenic variation in Giardia lamblia]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases. 2012 Aug 30;30(4):317-20

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PMID: 23072166

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