Changes in hemoglobin F levels in pregnant women unaffected by clinical fetomaternal hemorrhage.

Complete automation of high-performance liquid chromatography (HPLC) for determination of hemoglobin F (%Hb F) and hemoglobin A1c (%Hb A1c) levels has made this procedure available in many clinical laboratories. However, the physiological changes in %Hb F during pregnancy and the effects of physiological and supraphysiological levels of %Hb A1c on measurement of %Hb F have not been studied extensively. Simultaneous determination of %Hb F and %Hb A1c was conducted in 490 blood samples obtained before (n=21), during the 1st (n=150), 2nd (n=116), and 3rd (n=192) trimesters of pregnancy, and postpartum (n=11) from 357 women, including 60 women with hyperglycemia but unaffected by clinical fetomaternal hemorrhage, by HPLC. Mean (SD) Hb F levels were 0.71% (0.25%) before pregnancy. The value of 0.82% (0.47%) during the 1st trimester decreased significantly to 0.66% (0.35%) during the 2nd trimester and to 0.58% (0.38%) during the 3rd trimester. The level was 0.62% (0.31%) approximately one year after delivery. Thus, %Hb F was highest during the 1st trimester of pregnancy. The effects of varied %Hb A1c levels on %Hb F measurements were clinically negligible. The data presented in this work may be used as reference intervals of %Hb F determined with HPLC during pregnancy. Copyright © 2012 Elsevier B.V. All rights reserved.

Citation

Takashi Yamada, Mamoru Morikawa, Takahiro Yamada, Ryutaro Nishida, Masamitsu Takeda, Satoshi Kawaguchi, Hisanori Minakami. Changes in hemoglobin F levels in pregnant women unaffected by clinical fetomaternal hemorrhage. Clinica chimica acta; international journal of clinical chemistry. 2013 Jan 16;415:124-7

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PMID: 23073220

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