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The structures of WS1358A1 and B1, new dehydropeptidase inhibitors isolated from Streptomyces parvulus subsp. tochigiensis No. 1358, have been established to be 2-hydroxy-2-hydroxyaminocarbonyl-3-methylglutaric acid (1) and 2-hydroxy-2-hydroxyaminocarbonylglutaric acid (2), respectively, on the basis of spectroscopic evidence and synthesis of the racemates.


S Takase, I Uchida, S Hashimoto, H Tanaka, M Hashimoto. Studies on new dehydropeptidase inhibitors. II. Structural elucidation and synthesis of WS1358A1 and B1. The Journal of antibiotics. 1990 Jan;43(1):38-42

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PMID: 2307629

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