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The imidazoline system consists in imidazoline receptors I1, I2 and I3 and the active as well as that there are some endogenous ligands. We consider that one of the most important functions of this system is modulation of different types of behavior. Existent data show that I1 and I2 receptors have different effects on some behavior components, such as suicidal behavior, stress, anxiety, food intake etc. We consider that selective I1 and I2 agonists could become drugs to be used in the therapy of some behavioral disorders. The fact that some agonists or antagonists of imidazoline receptors have also effect on alpha-adrenergic receptors or MAO (monoamine oxidase) enlarges the use area of the compounds in behavioral disorders.


M Nechifor, Diana Ciubotariu. Behavioral involvement of imidazoline system. Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i. 2012 Apr-Jun;116(2):552-6

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PMID: 23077952

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