Hepatitis C virus recurrence and immunosuppression-free state after liver transplantation.

Tommaso Maria Manzia, Roberta Angelico, Luca Toti, Quirino Lai, Paolo Ciano, Mario Angelico, Giuseppe Tisone

UOC Trapianti d'Organo, Tor Vergata University, Rome, Italy. tomanzia@libero.it

Expert review of clinical immunology 2012 Sep

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HCV-related disease is the most common indication for liver transplantation (LT). HCV recurrence, which is almost universal, has a significant impact on patient and graft survival after LT and still represents a great unsolved issue for the liver transplant community. Several treatment strategies have been proposed. Since antiviral therapy has limited efficacy and can be administrated only in selected transplant recipients and additionally that immunosuppressive drugs have a negative impact on HCV re-infection, the achievement of an immunosuppression-free state after LT could play a central role in the avoidance of rapid HCV recurrence.

Citation

Tommaso Maria Manzia, Roberta Angelico, Luca Toti, Quirino Lai, Paolo Ciano, Mario Angelico, Giuseppe Tisone. Hepatitis C virus recurrence and immunosuppression-free state after liver transplantation. Expert review of clinical immunology. 2012 Sep;8(7):635-44