Differential regulation of tyrosine hydroxylase by continuous and intermittent hypoxia.

Gayatri Raghuraman, Nanduri R Prabhakar, Ganesh K Kumar

Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

Advances in experimental medicine and biology 2012

filter terms:

Although continuous hypoxia (CH) and intermittent hypoxia (IH) cause reduction in oxygen availability, organisms adapt to the effects of chronic CH whereas IH adversely impacts autonomic functions. Catecholamines are expressed both in the central and peripheral nervous systems and they play important roles in the regulation of cardio-respiratory functions during hypoxia. Tyrosine hydroxylase (TH) is the rate-limiting enzyme for catecholamine synthesis. Several studies have examined the effects of hypoxia on catecholamines by focusing on the regulation of TH. In this article, we present a brief overview of the impact of chronic CH and IH on TH expression, activity and the associated cellular mechanism(s).

Citation

Gayatri Raghuraman, Nanduri R Prabhakar, Ganesh K Kumar. Differential regulation of tyrosine hydroxylase by continuous and intermittent hypoxia. Advances in experimental medicine and biology. 2012;758:381-5