2'-F-ANA-guanosine and 2'-F-guanosine as powerful tools for structural manipulation of G-quadruplexes.

Christopher Jacques Lech, Zhe Li, Brahim Heddi, Anh Tuân Phan

School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore.

Chemical communications (Cambridge, England) 2012 Dec 4

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Here we demonstrate the applicability of 2'-F-ANA-guanosine and 2'-F-guanosine as powerful tools for manipulating G-quadruplex folding by anti-position-favoring substitutions. A single guanine to 2'-F-ANA-guanine substitution can favor a single (3+1) hybrid conformation from a mixture of conformers. Rational substitutions of either type of 2'-F-modified nucleotide enable conformational switching from a (3+1) hybrid to a parallel folding topology.

Citation

Christopher Jacques Lech, Zhe Li, Brahim Heddi, Anh Tuân Phan. 2'-F-ANA-guanosine and 2'-F-guanosine as powerful tools for structural manipulation of G-quadruplexes. Chemical communications (Cambridge, England). 2012 Dec 4;48(93):11425-7