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A nine year old female patient presented with complaints of severe colicky abdominal pain, vomiting, and tingling with numbness for 3 days. Acute necrotizing pancreatitis associated with tetany due to anti-retroviral therapy was diagnosed. Stavudine was the probable causal agent. Unfortunately, the patient died due to severity of the reaction. High index of suspicion and early withdrawal of the offending drug may prevent further harm in such cases.


Mahendra K Patel, Manish J Barvaliya, Tejas K Patel, C B Tripathi. Stavudine induced acute necrotizing pancreatitis with tetany in a pediatric patient. Indian journal of pharmacology. 2012 Jul-Aug;44(4):523-5

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PMID: 23087520

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