Daptomycin concentrations in valve tissue and vegetation in patients with bacterial endocarditis.

Carlo Tascini, Antonello Di Paolo, Roberta Poletti, Sarah Flammini, Michele Emdin, Ilaria Ciullo, Enrico Tagliaferri, Annette Moter, Francesco Menichetti

Antimicrobial agents and chemotherapy 2013 Jan

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In a patient with mitral-aortic native-valve Streptococcus oralis endocarditis, daptomycin concentrations in aortic and mitral valves were 8.6 and 30.8 μg/g, respectively, and 26 μg/g in the mitral vegetation. In the case of porcine-aortic-valve Staphylococcus epidermidis endocarditis, the daptomycin concentrations were 53.1 μg/g in the valve and 18.1 μg/g in perivalvular tissues. Daptomycin achieved apparently adequate tissue concentrations. S. epidermidis was eradicated, whereas Streptococcus oralis persisted, and its daptomycin MIC displayed a 4-fold increase.

Citation

Carlo Tascini, Antonello Di Paolo, Roberta Poletti, Sarah Flammini, Michele Emdin, Ilaria Ciullo, Enrico Tagliaferri, Annette Moter, Francesco Menichetti. Daptomycin concentrations in valve tissue and vegetation in patients with bacterial endocarditis. Antimicrobial agents and chemotherapy. 2013 Jan;57(1):601-2