Exposure to titanium dioxide nanoparticles induces autophagy in primary human keratinocytes.

Yun Zhao, Josephine L C Howe, Zhang Yu, David Tai Leong, Justin Jang Hann Chu, Joachim Say Chye Loo, Kee Woei Ng

School of Materials Science and Engineering, Nanyang Technological University, Singapore.

Small (Weinheim an der Bergstrasse, Germany) 2013 Feb 11

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Understanding the mechanisms of cell-nanomaterial interactions is vital in harnessing the potential of using nanomaterials in biomedical applications. By immuno-labeling of LC3 and TEM analysis, it is found that titanium dioxide nanoparticles are internalized by human keratinocytes and induce autophagy. Autophagy appears to play a cytoprotective role in response to toxicity influence exerted by the nanoparticles. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Yun Zhao, Josephine L C Howe, Zhang Yu, David Tai Leong, Justin Jang Hann Chu, Joachim Say Chye Loo, Kee Woei Ng. Exposure to titanium dioxide nanoparticles induces autophagy in primary human keratinocytes. Small (Weinheim an der Bergstrasse, Germany). 2013 Feb 11;9(3):387-92