Protein palmitoylation and pathogenesis in apicomplexan parasites.

Apicomplexan parasites comprise a broad variety of protozoan parasites, including Toxoplasma gondii, Plasmodium, Eimeria, and Cryptosporidium species. Being intracellular parasites, the success in establishing pathogenesis relies in their ability to infect a host-cell and replicate within it. Protein palmitoylation is known to affect many aspects of cell biology. Furthermore, palmitoylation has recently been shown to affect important processes in T. gondii such as replication, invasion, and gliding. Thus, this paper focuses on the importance of protein palmitoylation in the pathogenesis of apicomplexan parasites.

Citation

Maria Martha Corvi, Andres Mariano Alonso, Marina Cecilia Caballero. Protein palmitoylation and pathogenesis in apicomplexan parasites. Journal of biomedicine & biotechnology. 2012;2012:483969

Mesh Tags

Substances

PMID: 23093847

search → result