Polyneuropathy associated with monoclonal gammopathy of undetermined significance].

Marie Moth Henriksen, Eva Brøsted Kolmos, Niels Abildgaard, Henrik Daa Schrøder, Søren Sindrup

Neurologisk Afdeling, Odense Universitetshospital. mhen0085@regionh.dk

Ugeskrift for laeger 2012 Oct 22

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The prevalence of polyneuropathy in patients with monoclonal gammopathy of undetermined significance (MGUS) has been reported to be 10-50%. The majority of patients have a chronic, slowly progressive, distal, symmetric and predominantly sensory polyneuropathy. A caused relationship between polyneuropathy and immunoglobulin (Ig)M MGUS is better established than the relationship between polyneuropathy and IgG/IgA MGUS because of the observed binding of IgM to myelin sheaths and widening of myelin lamellae. In randomized controlled trials plasma exchange, immunosuppressive, rituximab and intravenous Ig have been found to have a clinical meaningful effect.

Citation

Marie Moth Henriksen, Eva Brøsted Kolmos, Niels Abildgaard, Henrik Daa Schrøder, Søren Sindrup. Polyneuropathy associated with monoclonal gammopathy of undetermined significance]. Ugeskrift for laeger. 2012 Oct 22;174(43):2630-4