Inhibitory potential of a novel imidazole derivative as evaluated by time-kill and dehydrogenase activity.

Florin Aonofriesei, Simona Lupsor

Current microbiology 2013 Feb

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Antibacterial activity of 1,1'-methandiylbis(2-methyl-1H-imidazole) (AIM) has been estimated both qualitatively and quantitatively against reference and clinical strains of Gram-positive and Gram-negative bacteria. MICs showed little variability among strains tested, ranging from 360 to 450 μg/ml and indicating rather a moderate antibacterial activity. Inhibition of dehydrogenase activity was significant in Escherichia coli ATCC 25922 and followed closely time-kill dynamics. Although moderate, AIM proved also to be useful on the ability to successfully inhibit the growth of antibiotic resistant clinical strains.

Citation

Florin Aonofriesei, Simona Lupsor. Inhibitory potential of a novel imidazole derivative as evaluated by time-kill and dehydrogenase activity. Current microbiology. 2013 Feb;66(2):162-8