Interaction between single nucleotide polymorphism in catalase gene and catalase activity under the conditions of oxidative stress.

A V Komina, K A Korostileva, S N Gyrylova, R N Belonogov, T G Ruksha

Department of Pathophysiology, Krasnoyarsk State Medical University Named After V. F. Voino-Yasenetsky, Russian Federation Ministry for Health and Social Development, Krasnoyarsk, Russia.

Physiological research / Academia Scientiarum Bohemoslovaca 2012

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Catalase is an antioxidant enzyme the activity of which is crucial for the protection against damage caused by reactive oxygen species. The -262C>T polymorphism in the promoter region of catalase gene was found to be associated with altered catalase levels. In this study, peripheral blood mononuclear cells catalase activity was measured after H(2)O(2)-induced oxidative stress. C/T and T/T genotypes were associated with the decrease of catalase levels in contrast to C/C donors who had elevated catalase activity in the presence of 0.4 and 0.7 mM H(2)O(2). Genotype-dependent response of catalase activity to oxid ative stress might be related to the predisposition of catalase mutant allele carriers to disorders mediated by oxidative stress.

Citation

A V Komina, K A Korostileva, S N Gyrylova, R N Belonogov, T G Ruksha. Interaction between single nucleotide polymorphism in catalase gene and catalase activity under the conditions of oxidative stress. Physiological research / Academia Scientiarum Bohemoslovaca. 2012;61(6):655-8