Pattern recognition receptors--molecular orchestrators of inflammation in inflammatory bowel disease.

David Walsh, Joanna McCarthy, Caitriona O'Driscoll, Silvia Melgar

Pharmacodelivery Group, School of Pharmacy, University College Cork, Ireland.

Cytokine & growth factor reviews 2013 Apr

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Pattern recognition receptors (PRRs) are a family of germline encoded receptors responsible for the detection of "pathogen associated molecular patterns" (PAMPs) or host derived "damage associated molecular patterns" (DAMPs) which induce innate immune signalling to generate a pro-inflammatory profile within the host. Four main classes of PRRs are recognised, Toll-like receptors (TLRs), NOD-like receptors (NLRs), RIG-like receptors (RLRs) and C-type lectin receptors (CLRs). Abnormal activation of PRRs has been implicated in various autoimmune and inflammatory conditions including rheumatoid arthritis and asthma. Recent growing evidence has implicated these PRRs as contributory elements to the pathogenesis of inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). Here, the current literature which implicates PRRs in IBD and CAC is comprehensively reviewed. Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

David Walsh, Joanna McCarthy, Caitriona O'Driscoll, Silvia Melgar. Pattern recognition receptors--molecular orchestrators of inflammation in inflammatory bowel disease. Cytokine & growth factor reviews. 2013 Apr;24(2):91-104