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The purpose of this research was to investigate the application of carbon dioxide (CO₂) ablation and determine if carbon dioxide plays a role in treating hepatocellular carcinoma. Twelve mice with subcutaneous xenografts of a hepatocellular cancer cell line were randomly separated into 2 groups. One group underwent CO₂ ablation with their liver tumor in vivo while the other group in vitro, respectively. All mice were killed on day 28. Hematoxylin-eosin (HE) staining was performed on the mice to estimate the pathological change. Just after 4 weeks, no significant difference in tumor size was detected between the two groups. The dimensions of the principal tumor varied from 2-3 cm with an average size of 2.2 cm in the greatest dimension. HE staining demonstrated an array of construct damage and necrosis in both groups. CO₂ ablation could be an important treatment in the management of cancer.


Dong-Yi Liang, Shi-Chun Zhou, Hongyu Zhou, Mingwei Tong. Carbon dioxide (CO₂) ablation as a remedy for hepatocellular carcinoma. Hepato-gastroenterology. 2013 Mar-Apr;60(122):346-8

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PMID: 23107935

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