Neurogenesis enhancer RO 25-6981 facilitates repeated spatial learning in adult rats.

O A Soloviova, A T Proshin, Z I Storozheva, V V Sherstnev

PK Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia. SAolga@yandex.ru

Bulletin of experimental biology and medicine 2012 Sep

filter terms:

The effects of Ro 25-6981 (selective NMDA receptor blocker) in a dose stimulating neurogenesis on repeated learning, reversal learning, and memory reconsolidation were studied in adult rats in Morris water maze. Ro 25-6981 facilitated repeated learning 13 days after injection, but did not influence reversal learning. The blocker injected directly before reminder did not disturb repeated learning and reversal learning in Morris water maze. These effects of Ro 25-6981 on the dynamics of repeated learning seemed to be due to its effects on neurogenesis processes in adult brain.

Citation

O A Soloviova, A T Proshin, Z I Storozheva, V V Sherstnev. Neurogenesis enhancer RO 25-6981 facilitates repeated spatial learning in adult rats. Bulletin of experimental biology and medicine. 2012 Sep;153(5):764-6