Homogenous bis-sulfonic acid ionic liquids (1 mol equiv.) in DMSO (10 mol equiv.) at 100 °C efficiently mediated the conversion of D-fructose into 5-hydroxymethyl-2-furfural in 75% isolated yield, which was roughly a 10% increment compared to the case of the mono-sulfonic acid ionic liquids.
Sang Eun Sim, Sunjeong Kwon, Sangho Koo. Bis-sulfonic acid ionic liquids for the conversion of fructose to 5-hydroxymethyl-2-furfural. Molecules (Basel, Switzerland). 2012 Oct 31;17(11):12804-11
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PMID: 23114616
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