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Allergic reactions to amide local anaesthetic agents are rare. We report the case of a 74-year-old man who suffered anaphylaxis, presenting with cardiovascular collapse, immediately after receiving regional anaesthesia on two separate occasions, the first involving the use of levobupivacaine and the second using ropivacaine. Skin testing revealed positive reactions to both levobupivacaine and ropivacaine, and negative reactions to articaine and lidocaine. Severe allergic reactions can be caused by the amide local anaesthetic drugs, levobupivacaine and ropivacaine. Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland.


A L Calderon, N Diot, F Benatir, F Christin, E Hautin, C Truc, B Allaouchiche, E Boselli. Immediate allergic cross-reactivity to levobupivacaine and ropivacaine. Anaesthesia. 2013 Feb;68(2):203-5

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PMID: 23121555

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