Botulinum toxin type A injection for neurogenic detrusor overactivity: clinical outcome in Japanese patients.

To report our experience with intravesical injection of botulinum toxin type A into the detrusor muscle of patients with neurogenic detrusor overactivity secondary to suprasacral spinal cord lesions or multiple sclerosis. Between January 2003 and March 2011, 11 patients (aged 23-75 years) were treated with 40 injections of botulinum toxin type A 300 U. The patients were followed up for 4, 8 and 12 weeks after treatment. The King's Health Questionnaire was administered and cystometric studies were carried out at baseline and 8 weeks after treatment. A total of six women and five men were treated. Analysis of the King's Health Questionnaire showed a significant improvement in eight of the nine domain scores at 8 weeks from baseline. On cystometric studies, the mean maximum cystometric capacity increased significantly in all patients at 8 weeks from baseline (P < 0.001). Bladder compliance also increased significantly (P < 0.001). The number of urinary incontinence episodes per day improved significantly from baseline after injection (4 weeks, P < 0.001; 8 weeks, P < 0.001; 12 weeks, P < 0.001). Lack of efficacy appeared 7.15 ± 3.4 months after treatment. Injection of botulinum toxin type A into the detrusor muscle of patients with neurogenic detrusor overactivity secondary to suprasacral spinal cord lesions or multiple sclerosis consistently improves bladder control and quality of life. © 2012 The Japanese Urological Association.

Citation

Katsuya Hikita, Masashi Honda, Bunya Kawamoto, Tsounapi Panagiota, Seiya Inoue, Nobuyuki Hinata, Kuniyasu Muraoka, Atsushi Takenaka. Botulinum toxin type A injection for neurogenic detrusor overactivity: clinical outcome in Japanese patients. International journal of urology : official journal of the Japanese Urological Association. 2013 Jan;20(1):94-9

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PMID: 23126535

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