The emergence of clinical resistance to tigecycline.

Yan Sun, Yun Cai, Xu Liu, Nan Bai, Beibei Liang, Rui Wang

Department of Clinical Pharmacology, PLA General Hospital, 28 Fu Xing Road, Beijing 100853, People's Republic of China.

International journal of antimicrobial agents 2013 Feb

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Tigecycline (TIG) exhibits broad-spectrum activity against many Gram-positive and Gram-negative pathogens. However, clinical resistance has emerged recently and has been detected following treatment with TIG. This observation suggests that long-term monotherapy may carry a high risk for TIG resistance. TIG resistance is observed most frequently in Acinetobacter baumannii and Enterobacteriaceae, especially in multidrug-resistant strains. Resistance-nodulation-cell division (RND)-type transporters and other efflux pumps may be factors for decreased sensitivity to TIG. Therefore, TIG should be cautiously used in the clinic, and efflux-mediated resistance should be closely monitored in order to prolong the lifespan of this useful antibiotic. Copyright © 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

Citation

Yan Sun, Yun Cai, Xu Liu, Nan Bai, Beibei Liang, Rui Wang. The emergence of clinical resistance to tigecycline. International journal of antimicrobial agents. 2013 Feb;41(2):110-6