Caught in translation: innate restriction of HIV mRNA translation by a schlafen family protein.

Martin R Jakobsen, Trine H Mogensen, Søren R Paludan

Cell research 2013 Mar

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Human immunodeficiency virus type 1 (HIV-1) is the cause of AIDS. In recent years it has emerged that cellular interferon-stimulated genes (ISG), play important roles in cell-intrinsic restriction of HIV replication. A publication now describes a novel strategy employed by HIV-infected cells to restrict viral replication, which involves inhibition of viral mRNA translation by the ISG Schlafen 11.

Citation

Martin R Jakobsen, Trine H Mogensen, Søren R Paludan. Caught in translation: innate restriction of HIV mRNA translation by a schlafen family protein. Cell research. 2013 Mar;23(3):320-2