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Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.
Rania M Deranieh, Miriam L Greenberg, Pierre-B Le Calvez, Maura C Mooney, Marie E Migaud
Organic & biomolecular chemistry 2012 Dec 28Sizes of these terms reflect their relevance to your search.
The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.
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Rania M Deranieh, Miriam L Greenberg, Pierre-B Le Calvez, Maura C Mooney, Marie E Migaud. Probing myo-inositol 1-phosphate synthase with multisubstrate adducts. Organic & biomolecular chemistry. 2012 Dec 28;10(48):9601-19
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PMID: 23132282
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