Mitochondrial network size scaling in budding yeast.

Susanne M Rafelski, Matheus P Viana, Yi Zhang, Yee-Hung M Chan, Kurt S Thorn, Phoebe Yam, Jennifer C Fung, Hao Li, Luciano da F Costa, Wallace F Marshall

Science (New York, N.Y.) 2012 Nov 09

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Mitochondria must grow with the growing cell to ensure proper cellular physiology and inheritance upon division. We measured the physical size of mitochondrial networks in budding yeast and found that mitochondrial network size increased with increasing cell size and that this scaling relation occurred primarily in the bud. The mitochondria-to-cell size ratio continually decreased in aging mothers over successive generations. However, regardless of the mother's age or mitochondrial content, all buds attained the same average ratio. Thus, yeast populations achieve a stable scaling relation between mitochondrial content and cell size despite asymmetry in inheritance.

Citation

Susanne M Rafelski, Matheus P Viana, Yi Zhang, Yee-Hung M Chan, Kurt S Thorn, Phoebe Yam, Jennifer C Fung, Hao Li, Luciano da F Costa, Wallace F Marshall. Mitochondrial network size scaling in budding yeast. Science (New York, N.Y.). 2012 Nov 09;338(6108):822-4