A biocatalytic hydrogenation of carboxylic acids.
Yan Ni, Peter-Leon Hagedoorn, Jian-He Xu, Isabel W C E Arends, Frank Hollmann
Delft University of Technology, Department of Biotechnology, Julianalaan 136, 2628BL Delft, The Netherlands.
Chemical communications (Cambridge, England) 2012 Dec 25The hyperthermophile Pyrococcus furiosus catalyses the hydrogenation of a broad range of carboxylic acids selectively to the corresponding primary alcohols. Other functional groups such as isolated C=C-double bonds are not touched. The chemoselectivity of the carboxylate reduction may be directed towards aldehydes by simple medium engineering.
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Yan Ni, Peter-Leon Hagedoorn, Jian-He Xu, Isabel W C E Arends, Frank Hollmann. A biocatalytic hydrogenation of carboxylic acids. Chemical communications (Cambridge, England). 2012 Dec 25;48(99):12056-8
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PMID: 23139934
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