Correlation Engine 2.0
Clear Search sequence regions

Corticosteroids and cyclosporine A (CsA) are important clinical immunosuppressive drugs used in the maintenance of organ transplants and in suppressing undesired autoimmune or allergic immune responses. To study the effect of CsA and prednisolone on the course of an Ancylostoma ceylanicum infection, hamsters were treated with commercially available prednisolone or CsA. For both drugs, half the recommended dose was sufficient to inhibit the proliferation of more than 70% of hamster lymph node cells. There was no difference in the recovery of adult worms; however, animals treated with prednisolone presented with low egg counts in the feces. Infection with A. ceylanicum resulted in an increase in specific antibodies against adult worm antigens, but hamsters treated with either drug presented with lower IgG titers. We observed that A. ceylanicum infection caused peripheral cellular immune suppression, which is characterized by a reduction in the total white cell count, neutropenia and lymphopenia. We also observed a lymphoplasmacytic pattern and few eosinophils in the mucosal inflammatory infiltrate for all the animals. The animals treated with prednisolone showed changes in the architecture of the intestine, including the loss of the mucosa, intense congestion and inflammation. In spleen, we observed hyperplasia of white pulp in all infected animals; in addition, there was a loss of tissue architecture in the animals treated with prednisolone. In conclusion, this work shows that an A. ceylanicum infection leads to acute peripheral cellular immune suppression in hamsters but not humoral immune suppression and that CsA treatment does not interfere with the process of infection. However, prednisolone treatment causes intestinal injury, what could hamper the parasite attachment to the intestinal wall, and as a result affects copulation and, consequently, decreases the number of eggs eliminated in the feces. Moreover, the possibility that the drug can also be exerting an effect on female fertility should be considered. Copyright © 2012 Elsevier Inc. All rights reserved.


Sílvia Regina Costa Dias, Ana Flávia Dias Vieira da Costa, Pedro Henrique Gazzinelli-Guimarães, Bruno Mendes Roatt, Kátia da Silva Fonseca, Nívia Carolina Nogueira de Paiva, Rodolfo Cordeiro Giunchetti, Cláudia Martins Carneiro, Ricardo Toshio Fujiwara, Élida Mara Leite Rabelo. Prednisolone and cyclosporine A: effects on an experimental model of ancylostomiasis. Experimental parasitology. 2013 Jan;133(1):80-8

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 23142084

View Full Text