Atomoxetine increases fronto-parietal functional MRI activation in attention-deficit/hyperactivity disorder: a pilot study.

George Bush, Jennifer Holmes, Lisa M Shin, Craig Surman, Nikos Makris, Eric Mick, Larry J Seidman, Joseph Biederman

Psychiatry research 2013 Jan 30

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We hypothesized that atomoxetine (ATMX) would produce similar brain effects in attention-deficit/hyperactivity disorder (ADHD) as those of methylphenidate (MPH). Eleven ADHD adults performed the Multi-Source Interference Task (MSIT) during functional magnetic resonance imaging (fMRI) at baseline and after 6 weeks of ATMX treatment. ATMX was associated with increased fMRI activation of dorsolateral prefrontal cortex, parietal cortex and cerebellum but not dorsal anterior midcingulate cortex (daMCC). These results suggest that ATMX and MPH have similar but not identical brain effects. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Citation

George Bush, Jennifer Holmes, Lisa M Shin, Craig Surman, Nikos Makris, Eric Mick, Larry J Seidman, Joseph Biederman. Atomoxetine increases fronto-parietal functional MRI activation in attention-deficit/hyperactivity disorder: a pilot study. Psychiatry research. 2013 Jan 30;211(1):88-91