Expression of costimulatory molecule B7-H4 in human malignant tumors.
Xiao Zheng, Xiao-Dong Li, Chang-Ping Wu, Bin-Feng Lu, Jing-Ting Jiang
Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Onkologie 2012Costimulatory molecule B7-H4, a member of the B7 family, negatively regulates the immune response of T cells through inhibiting their proliferation, cytokine production and cell cycle. The overexpression of B7-H4 plays an important role in initiation, progression and regression of tumors by promoting malignant transformation of epithelial cells and protecting epithelial cells from anoikis. B7-H4 expression in malignant tumors is useful for clinical diagnosis, and may provide a novel molecular target for cancer treatment.
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Xiao Zheng, Xiao-Dong Li, Chang-Ping Wu, Bin-Feng Lu, Jing-Ting Jiang. Expression of costimulatory molecule B7-H4 in human malignant tumors. Onkologie. 2012;35(11):700-5
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PMID: 23147549
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