Correlation Engine 2.0
Clear Search sequence regions


  • angiogenesis (1)
  • cell (3)
  • cell movement (1)
  • egf like (4)
  • growth factor (5)
  • Hbegf (1)
  • Hbegf (6)
  • hbegf protein, human (1)
  • heparin (5)
  • human (2)
  • injuries (1)
  • layer (1)
  • mice (2)
  • peptides (2)
  • protein human (1)
  • vitro (2)
  • wound (9)
  • Sizes of these terms reflect their relevance to your search.

    Wound healing is a dynamic process that relies on coordinated signaling molecules to succeed. Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is proven to accelerate healing, however precise control over its application is necessary to reduce side effects and achieve desired therapeutic benefit. To achieve effective growth factor delivery we designed a bioactive heparin-based coacervate. In vitro, HB-EGF released from the coacervate delivery system displayed enhanced bioactivity and promoted human keratinocyte migration while preserving cell proliferative capability. In a mouse excisional full-thickness wound model, controlled release of HB-EGF within the wound significantly accelerated wound closure more effectively than an equal dosage of free HB-EGF. Healing was induced by rapid re-epithelialization, granulation tissue formation, and accompanied by angiogenesis. Consistent with in vitro results, wounds treated with HB-EGF coacervate exhibited enhanced migration of keratinocytes with retained proliferative potential, forming a confluent layer for regained barrier function within 7 days. Collectively, these results suggest that coacervate-based controlled release of HB-EGF may serve as a new therapy to accelerate healing of cutaneous wounds. Copyright © 2012 Elsevier B.V. All rights reserved.

    Citation

    Noah Ray Johnson, Yadong Wang. Controlled delivery of heparin-binding EGF-like growth factor yields fast and comprehensive wound healing. Journal of controlled release : official journal of the Controlled Release Society. 2013 Mar 10;166(2):124-9

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 23154193

    View Full Text