Human radiation dose estimation of (11)C-CFT using whole-body PET.

Tingting Huang, Hongliang Wang, Ganghua Tang, Xiang Liang, Huaifu Deng, Chang Yi, Xiangsong Zhang

Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.

Clinical nuclear medicine 2012 Dec

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C-Labeled 2-β-carbomethoxy-3-β-(4-fluorophenyl)tropane (C-CFT) is a commonly used positron emission tomography (PET) tracer for dopamine transporters imaging. The present study estimated human radiation absorbed doses of C-CFT based on whole-body PET imaging in healthy subjects. Whole-body PET was performed on 6 subjects after injection of 472.06 ± 116.47 MBq of C-CFT. 7 Frames were acquired for about 70 min in 7 segments of the body. Regions of interest were drawn on PET images of source organs. Residence time was calculated as the area under the time-activity curve. Radiation dosimetry was calculated from organ residence time using the medical internal radiation dosimetry (MIDR) method. The organs with the highest radiation-absorbed doses were the urinary bladder, followed the spleen, pancreas, kidneys, and stomach. The dose-limiting critical organ was the urinary bladder. The effective dose was 8.89E-03 mSv/MBq (22.9 mrem/mCi). Biexponential fitting of mean bladder activity demonstrated that 18% of activity was excreted via the urine. The potential radiation risks of C-CFT associated with in this study are well within accepted limits. C-CFT demonstrates a favorable radiation dose profile in humans and allows multiple PET examinations on the same subject per year.

Citation

Tingting Huang, Hongliang Wang, Ganghua Tang, Xiang Liang, Huaifu Deng, Chang Yi, Xiangsong Zhang. Human radiation dose estimation of (11)C-CFT using whole-body PET. Clinical nuclear medicine. 2012 Dec;37(12):1159-62