Identification of pavinane alkaloids in the genera Argemone and Eschscholzia by GC-MS.

Lucie Cahlíková, Radim Kucera, Anna Host'álková, Jirí Klimes, Lubomír Opletal

ADINACO Research Group, Department ofPharmaceutical Botany and Ecology, Charles University, Heyrovskdho 1203, 500 05 Hradec Kralovd, Czech Republic. cahlikova@faf.cuni.cz

Natural product communications 2012 Oct

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The genera Eschscholtzia and Argemone (Papaveraceae) represent a rich source of pavinane alkaloids, the identification of which in alkaloid extracts is generally problematic without standards. The alkaloid extracts of three Argemone and four Eschscholtzia species were analyzed using GC-MS. The alkaloids were identified based on comparison of their mass spectra with commercial libraries, with reported data in the literature and with spectra of reference compounds. A total of 23 alkaloids of six structural types (pavinane, protopine, benzylisoquinoline, benzophenanthridine, aporphine and protoberberine) were identified. The fragmentation pathway of pavinane alkaloids was used for their identification. O-Methylneocaryachine has been reported for the first time from a natural sources and the alkaloid pattern of Eschscholzia pulchella has been analyzed and described for the first time.

Citation

Lucie Cahlíková, Radim Kucera, Anna Host'álková, Jirí Klimes, Lubomír Opletal. Identification of pavinane alkaloids in the genera Argemone and Eschscholzia by GC-MS. Natural product communications. 2012 Oct;7(10):1279-81