Non-fouling hydrogels of 2-hydroxyethyl methacrylate and zwitterionic carboxybetaine (meth)acrylamides.

Nina Yu Kostina, Cesar Rodriguez-Emmenegger, Milan Houska, Eduard Brynda, Jiří Michálek

Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v.v.i., Prague, 16206, Czech Republic.

Biomacromolecules 2012 Dec 10

filter terms:

Five poly(betaine) brushes were prepared, and their resistance to blood plasma fouling was studied. Two carboxybetaines monomers were copolymerized with 2-hydroxyethyl methacrylate (HEMA) to prepare novel hydrogels. By increasing the content of the zwitterionic comonomer, a 4-fold increase in the water content could be achieved while retaining mechanical properties close to the widely used poly(HEMA) hydrogels. All hydrogels showed an unprecedentedly low fouling from blood plasma. Remarkably, by copolymerization with 10 mol % of carboxybetaine acrylamide, hydrogels fully resistant to blood plasma were prepared.

Citation

Nina Yu Kostina, Cesar Rodriguez-Emmenegger, Milan Houska, Eduard Brynda, Jiří Michálek. Non-fouling hydrogels of 2-hydroxyethyl methacrylate and zwitterionic carboxybetaine (meth)acrylamides. Biomacromolecules. 2012 Dec 10;13(12):4164-70