Anti-β2 glycoprotein I antibodies and pregnancy outcome in antiphospholipid syndrome.

Xin Li Liu, Jing Xiao, Fufan Zhu

Department of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Acta obstetricia et gynecologica Scandinavica 2013 Feb

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The relation between pregnancy outcome and single- or double-positivity of anticardiolipin (aCL) and β2 glycoprotein I (aβ2GPI) in antiphospholipid syndrome (APS) has yet to be clearly documented. In this article, a total of 191 lupus anticoagulant-negative pregnant women with primary APS were retrospectively divided into three groups: aCL(+) /aβ2GPI(-) ; aCL(+) /aβ2GPI(+) ; aCL(-) /aβ2GPI(+) . All women had received medical therapy consisting of prednisone (10-15 mg/day), low-dose aspirin (50 mg/day), and low molecular weight heparin (40 mg/day). The miscarriage rate in the double-positive group was significantly higher than that in the aCL(+) /aβ2GPI(-) group (46.2% vs. 22.1%, p < 0.05); the miscarriage rate in the aCL(-) /aβ2GPI(+) group (36.4%) was not significantly different from the rates of the other two groups (p > 0.05). Thus, double-positivity may be a risk factor for pregnancy loss and aβ2GPI antibody may be a better prognostic marker than aCL antibody for pregnancy outcome. © 2012 The Authors Acta Obstetricia et Gynecologica Scandinavica © 2012 Nordic Federation of Societies of Obstetrics and Gynecology.

Citation

Xin Li Liu, Jing Xiao, Fufan Zhu. Anti-β2 glycoprotein I antibodies and pregnancy outcome in antiphospholipid syndrome. Acta obstetricia et gynecologica Scandinavica. 2013 Feb;92(2):234-7