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We describe a novel 7-aminopyrazolo[1,5-a]pyrimidine (7-APP) derivative as a potent hepatitis C virus (HCV) inhibitor. A series of 7-APPs was synthesized and evaluated for inhibitory activity against HCV in different cell culture systems. The synthesis and preliminary structure-activity relationship study of 7-APP are reported. Copyright © 2012 Elsevier Ltd. All rights reserved.


Jong Yeon Hwang, Marc Peter Windisch, Suyeon Jo, Keumhyun Kim, Sunju Kong, Hyoung Cheul Kim, Soohyun Kim, Heeyoung Kim, Myung Eun Lee, Youngmi Kim, Jihyun Choi, Dong-Sik Park, Eunjung Park, Jeongjin Kwon, Jiyoun Nam, Sujin Ahn, Jonathan Cechetto, Junwon Kim, Michel Liuzzi, Zaesung No, Jinhwa Lee. Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor. Bioorganic & medicinal chemistry letters. 2012 Dec 15;22(24):7297-301

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PMID: 23159569

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