An investigation of Ph(1) chromosome in Chronic Myeloid Leukemia patients with different treatment modalities and hematological features.

Chronic myeloid leukemia (CML) is characterized by a Ph(1) chromosome that derives through a translocation between chromosomes 9 and 22, i.e., t (9;22). Identifying the Ph(1) chromosome through cytogenetic analysis is an important aspect of CML diagnosis. The aim of this study was to determine the significance of cytogenetic analysis in the diagnosis of CML as well as to find out a relationship between chromosomal abnormalities and CML patients in different stages of treatment. Six CML patients were investigated for this study. The presence of Ph(1) chromosome was detected at different times of treatment using GTG banding on peripheral blood or bone marrow aspirations, and the results were analyzed using cytovision workstation. Hematological features were compared between newly diagnosed patients and patients under treatment. The Ph(1) chromosome was strongly associated with all cases of CML. The regression of Ph(1) chromosomes differed for each patient depending on the treatments and individual response to specific treatments.

Citation

Koushik Chattopadhyay, Bibhas Kar. An investigation of Ph(1) chromosome in Chronic Myeloid Leukemia patients with different treatment modalities and hematological features. Indian journal of human genetics. 2012 May;18(2):229-32

PMID: 23162301

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