Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study.

Chemical communications (Cambridge, England) 2013 Mar 21

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The development of a new class of surfactants for membrane protein manipulation, "GNG amphiphiles", is reported. These amphiphiles display promising behavior for membrane proteins, as demonstrated recently by the high resolution structure of a sodium-pumping pyrophosphatase reported by Kellosalo et al. (Science, 2012, 337, 473).

Citation

Pil Seok Chae, Rohini R Rana, Kamil Gotfryd, Søren G F Rasmussen, Andrew C Kruse, Kyung Ho Cho, Stefano Capaldi, Emil Carlsson, Brian Kobilka, Claus J Loland, Ulrik Gether, Surajit Banerjee, Bernadette Byrne, John K Lee, Samuel H Gellman. Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study. Chemical communications (Cambridge, England). 2013 Mar 21;49(23):2287-9