Decrease in RNA folding cooperativity by deliberate population of intermediates in RNA G-quadruplexes.

Chun Kit Kwok, Madeline E Sherlock, Philip C Bevilacqua

Department of Chemistry, The Pennsylvania State University, University Park, 16802, USA.

Angewandte Chemie (International ed. in English) 2013 Jan 7

filter terms:

Keeping a broad (RNA) perspective: conventional biochemical detection systems only have a 100-fold linear response range. The range of potassium concentrations detected by an RNA G-quadruplex sequence can be broadened by intentionally populating multiple intermediate folding states. The folding of the RNA G-quadruplexes was monitored by both circular dichroism and intrinsic fluorescence spectroscopy. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Chun Kit Kwok, Madeline E Sherlock, Philip C Bevilacqua. Decrease in RNA folding cooperativity by deliberate population of intermediates in RNA G-quadruplexes. Angewandte Chemie (International ed. in English). 2013 Jan 7;52(2):683-6