Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

Much effort is being devoted for developing new indicators to evaluate the human exposure to Aedes mosquito bites and the risk of arbovirus transmission. Human antibody (Ab) responses to mosquito salivary components could represent a promising tool for evaluating the human-vector contact. To develop a specific biomarker of human exposure to Aedes aegypti bites, we measured IgG Ab response to Ae. aegypti Nterm-34 kDa salivary peptide in exposed children in 7 villages of Southern Benin (West Africa). Results showed that specific IgG response presented high inter-individual heterogeneity between villages. IgG response was associated with rainfall and IgG level increased from dry (low exposure) to rainy (high exposure) seasons. These findings indicate that IgG Ab to Nterm-34 kDa salivary peptide may represent a reliable biomarker to detect variation in human exposure to Ae. aegypti bites. This preliminary study highlights the potential use of Ab response to this salivary peptide for evaluating human exposure to Ae. aegypti. This biomarker could represent a new promising tool for assessing the risk of arbovirus transmission and for evaluating the efficacy of vector control interventions.


Emmanuel Elanga Ndille, Souleymane Doucoure, Georgia Damien, François Mouchet, Papa Makhtar Drame, Sylvie Cornelie, Herbert Noukpo, Sandra Yamadjako, Armel Djenontin, Nicolas Moiroux, Dorothee Misse, Martin Akogbeto, Vincent Corbel, Marie-Claire Henry, Fabrice Chandre, Thierry Baldet, Franck Remoue. First attempt to validate human IgG antibody response to Nterm-34kDa salivary peptide as biomarker for evaluating exposure to Aedes aegypti bites. PLoS neglected tropical diseases. 2012;6(11):e1905

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 23166852

View Full Text