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We have developed a system to release a biologically active molecule in response to the sequence of a target gene. The releasing system, which was triggered by the reduction of an azidomethyl group, was successfully applied to protein expression induced by the release of IPTG triggered by endogenous RNA in bacterial cells.


Aya Shibata, Yoshihiro Ito, Hiroshi Abe. RNA-templated molecule release induced protein expression in bacterial cells. Chemical communications (Cambridge, England). 2013 Jan 11;49(3):270-2

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PMID: 23174744

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